Immunoreactive myelin basic protein in cerebrospinal fluid of patients with peripheral neuropathies.

Abstract

The presence of myelin basic protein (MBP)-like material in cerebrospinal fluid (CSF) usually reflects breakdown of central nervous system myelin. Immunoreactive MBP levels were measured in 70 CSF specimens from 66 patients with a variety of peripheral neuropathies. Immunoreactive MBP was present in CSF in 70% (16 of 23) of patients with biopsy-proved chronic demyelinating polyneuropathies, whereas in neuropathies producing primarily axonal damage it was present in only 22% (5 of 23). In Guillain-Barré syndrome, 45% (9 of 20) of patients had immunoreactive MBP in the CSF. We conclude that MBP-like material is present in the CSF of most patients with longstanding demyelinating polyradiculoneuropathies and probably reflects detection of peripheral nervous system P1 protein.

• Authors: D R Cornblath, J W Griffin, G I Tennekoon
• Journal: Annals of neurology (Ann Neurol) Vol. 20 Issue 3 Pg. 370-2 (Sep 1986) ISSN: 0364-5134 [Print] United States
• PMID: 2429614 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Myelin Basic Protein

Topics

• Demyelinating Diseases (cerebrospinal fluid)
• Humans
• Myelin Basic Protein (cerebrospinal fluid)
• Peripheral Nervous System Diseases (cerebrospinal fluid)
• Polyradiculoneuropathy (cerebrospinal fluid)