Abstract | BACKGROUND: METHODS: Twenty patients were enrolled and demographic, hemodynamic, cardiopulmonary bypass, and use of vasoactive medication data were collected. In addition, perioperative serum vasopressin levels were measured. Sixty adult patients undergoing left-sided cardiac surgery served as controls. RESULTS: The incidence of vasoplegia in the control patients was 10% and the incidence in the adult patients with right-sided congenital heart disease was 20%. Vasopressin levels were low at baseline (0.5 ± 0.5 pg/mL), increased slightly after induction of anesthesia (0.6 ± 0.6 pg/mL), increased after initiation of cardiopulmonary bypass (99.7 ± 168.2 pg/mL), and decreased after surgery (31.3 ± 43.6 pg/mL). CONCLUSIONS: This study showed that the incidence of vasoplegia (20%) in patients with right-sided congenital heart disease undergoing cardiac surgery was double that of a population of patients undergoing aortic valve surgery (10%). Serum vasopressin concentration was not associated with vasoplegia in this population of congenital cardiac surgical patients.
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Authors | Erica D Wittwer, James J Lynch, William C Oliver Jr, Joseph A Dearani, Harold M Burkhart, William J Mauermann |
Journal | The Journal of thoracic and cardiovascular surgery
(J Thorac Cardiovasc Surg)
Vol. 148
Issue 2
Pg. 625-30
(Aug 2014)
ISSN: 1097-685X [Electronic] United States |
PMID | 24280713
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Copyright | Copyright © 2014 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved. |
Chemical References |
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Biomarkers
(blood)
- Cardiac Surgical Procedures
(adverse effects)
- Cardiopulmonary Bypass
(adverse effects)
- Female
- Heart Defects, Congenital
(blood, surgery)
- Hemodynamics
- Humans
- Incidence
- Male
- Middle Aged
- Minnesota
(epidemiology)
- Prospective Studies
- Risk Factors
- Time Factors
- Treatment Outcome
- Vasoplegia
(blood, diagnosis, epidemiology, physiopathology)
- Vasopressins
(blood)
- Young Adult
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