Abstract | BACKGROUND: OBJECTIVE: METHODS: We searched Cochrane Central Register of Controlled Trials, PubMed, Embase, Web of science, clinical trial registry web sites (clinical trials,WHO clinical trial registry), Googlescholar, PubMed related articles and companies' web sites electronically up to Dec 30(th), 2012 and manually searched the reference lists and conference proceedings. Only randomized controlled trial (RCT) involving adult patients comparing idraparinux and/or idrabiotaparinux versus other anticoagulation methods for long-term VTE treatment was included. Two reviewers evaluated the studies and extracted data independently. Pooled risk ratios (RRs) were calculated as outcome measures and Revman 5.2 software was used to analyze data. Our primary efficacy and safety outcomes were the recurrent VTE and major bleeding rates. RESULTS: We included four RCTs and involved 8584 participants on idraparinux or idrabiotaparinux versus standard warfarin for VTE treatment from 9364 references. We did not perform meta-analysis on the VTE rate because of the significant heterogeneity. We used the fixed effect model to analyze the safety outcomes and demonstrated that idraparinux or idrabiotaparinux decreased major bleeding rate significantly (RR 0.73, 95% CI 0.54 to 0.98, Pā=ā0.04) but had a trend to increase the all cause mortality (RR 1.26, 95% CI 1.00 to 1.57, Pā=ā0.05) compared with warfarin. CONCLUSIONS:
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Authors | Yanzhi Song, Xiaodong Li, Settipalli Pavithra, Dong Li |
Journal | PloS one
(PLoS One)
Vol. 8
Issue 11
Pg. e78972
( 2013)
ISSN: 1932-6203 [Electronic] United States |
PMID | 24278113
(Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)
|
Chemical References |
- Oligosaccharides
- idraparinux
- Biotin
- idrabiotaparinux
|
Topics |
- Biotin
(adverse effects, analogs & derivatives, therapeutic use)
- Humans
- Oligosaccharides
(adverse effects, therapeutic use)
- Randomized Controlled Trials as Topic
- Venous Thromboembolism
(drug therapy)
|