Reduction of vanadate by some psychotropic drugs (chlorpromazine, imipramine and dosulepin) and the effect of bleomycine on Na, K-ATPase.

Abstract

The reduction of vanadate (+5V) to vanadyl (+4V) was demonstrated by ESR spectra in the presence of methylene-blue, chlorpromazine, imipramine and dosulepin, but not in the presence of benzodiazepines and Li+. Bleomycine forms an (inactive) complex with +4V which may explain the disinhibition of the brain microsomal Na+-K+ ATPase in the presence of vanadyl. The reduction of +5V to +4V by antidepressants would diminish the binding of +5V to the ATPase and could account for some of the therapeutic action of the drugs in manic-depressive illness.

• Authors: F Vyskocil, H Zemková, J Teisinger, J Pilar
• Journal: Physiologia Bohemoslovaca (Physiol Bohemoslov) Vol. 34 Suppl Pg. 171-5 ( 1985) ISSN: 0369-9463 [Print] Czech Republic
• PMID: 2425386 (Publication Type: Journal Article)

Chemical References

• Psychotropic Drugs
• Vanadium
• Bleomycin
• Vanadates
• Sodium-Potassium-Exchanging ATPase
• Imipramine
• Chlorpromazine
• Dothiepin

Topics

• Animals
• Bleomycin (pharmacology)
• Brain (enzymology)
• Chlorpromazine (pharmacology)
• Dothiepin (pharmacology)
• Imipramine (pharmacology)
• In Vitro Techniques
• Mice
• Oxidation-Reduction
• Psychotropic Drugs (pharmacology)
• Sodium-Potassium-Exchanging ATPase (metabolism)
• Vanadates
• Vanadium (metabolism)