How to correct chromosomal trisomy.

Abstract

Trisomy 21 in human causes Down syndrome, a common chromosome disorder with devastating phenotypes ranging from early death in utero to intellectual disability together with an array of physical anomalies and late-onset diseases. In a recent study published in Nature, Jeanne Lawrence and her colleagues restored normal gene expression in trisomy 21 cells by silencing the extra chromosome using XIST, the non-coding RNA that normally silences one X chromosome in females; this improved growth and differentiation of neural cells, which offers hope that some deleterious effects of the trisomy could be reversed to improve this incurable disease.

• Authors: Christine M Disteche
• Journal: Cell research (Cell Res) Vol. 23 Issue 12 Pg. 1345-6 (Dec 2013) ISSN: 1748-7838 [Electronic] England
• PMID: 24080727 (Publication Type: Journal Article, Comment)

Chemical References

• RNA, Long Noncoding

Topics

• Animals
• Chromosomes, Human, Pair 21 (genetics)
• Dosage Compensation, Genetic
• Down Syndrome (genetics)
• Humans
• Male
• RNA, Long Noncoding (metabolism)