Is buspirone effective for panic disorder?

Abstract

Buspirone was compared with imipramine and placebo in the treatment of panic disorder in an 8-week, double-blind controlled study of 52 randomly assigned patients. The side effect profile of buspirone was less disruptive than that of imipramine. Buspirone was not significantly superior to placebo in its antipanic or anxiolytic effects in panic disorder patients.

• Authors: D V Sheehan, A B Raj, K H Sheehan, S Soto
• Journal: Journal of clinical psychopharmacology (J Clin Psychopharmacol) Vol. 10 Issue 1 Pg. 3-11 (Feb 1990) ISSN: 0271-0749 [Print] United States
• PMID: 2407755 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Imipramine
• Buspirone

Topics

• Adult
• Agoraphobia (drug therapy)
• Anxiety Disorders (drug therapy, psychology)
• Arousal (drug effects)
• Buspirone (therapeutic use)
• Double-Blind Method
• Fear (drug effects)
• Female
• Follow-Up Studies
• Humans
• Imipramine (therapeutic use)
• Male
• Panic (drug effects)
• Phobic Disorders (drug therapy, psychology)
• Psychiatric Status Rating Scales
• Randomized Controlled Trials as Topic
• Single-Blind Method