Predictors of response and remission in a large cohort of rheumatoid arthritis patients treated with tocilizumab in clinical practice.

Abstract

OBJECTIVE:

The objective of this study was to identify predictors of response and remission to tocilizumab (TCZ) in RA patients seen in daily routine clinical practice.

METHODS:

The efficacy of TCZ was evaluated after 12 and 24 weeks of treatment by the European League Against Rheumatism (EULAR) response criteria. Regression analysis was performed to study the association between remission or EULAR response and the following characteristics: gender, age, current smokers, prior cardiovascular disease (CVD), 28-joint disease activity score (DAS28), CRP, RF or ACPA positivity, combination therapy with DMARDs and TCZ as the first biological therapy or after failure of at least one biological therapy.

RESULTS:

In total, 204 patients were included with a mean DAS28 score of 5.14. EULAR response and remission were obtained in 86.1% and 40% of patients, respectively, at week 24. In multiple regression analysis, a high baseline CRP level [odds ratio (OR) 4.454 (95% CI 1.446, 13.726)] was significantly associated with EULAR response at week 24 and, inversely, age >55 years [OR 0.285 (95% CI 0.086, 0.950)] and prior CVD [OR 0.305 (95% CI 0.113, 0.825)] were significantly associated with lower EULAR response at week 24. Older age was also associated with less remission at week 24 [OR 0.948 (95% CI 0.920, 0.978)]. No additional effectiveness was found when TCZ was used in combination with a DMARD or when patients were naive to biological agents.

CONCLUSION:

In daily practice we identified three predictors of a better response for TCZ therapy in RA: a younger age, a high baseline CRP level and no history of CVD.

• Authors: Yves-Marie Pers, Clémentine Fortunet, Elodie Constant, Joseph Lambert, Marie Godfrin-Valnet, Audrey De Jong, Grégoire Mercier, Béatrice Pallot Prades, Daniel Wendling, Philippe Gaudin, Christian Jorgensen, Hubert Marotte, Jean-Francis Maillefert
• Journal: Rheumatology (Oxford, England) (Rheumatology (Oxford)) Vol. 53 Issue 1 Pg. 76-84 (Jan 2014) ISSN: 1462-0332 [Electronic] England
• PMID: 24056521 (Publication Type: Comparative Study, Journal Article, Multicenter Study)

Chemical References

• Antibodies, Monoclonal, Humanized
• Tumor Necrosis Factor-alpha
• tocilizumab

Topics

• Antibodies, Monoclonal, Humanized (therapeutic use)
• Arthritis, Rheumatoid (diagnosis, drug therapy, metabolism)
• Female
• Follow-Up Studies
• Humans
• Male
• Middle Aged
• Prognosis
• ROC Curve
• Remission Induction
• Retrospective Studies
• Severity of Illness Index
• Treatment Outcome
• Tumor Necrosis Factor-alpha (antagonists & inhibitors, metabolism)