This study aimed to assess seminal
androgens,
oestradiol,
progesterone levels in oligoasthenoteratozoospermic (OAT) men with
varicocele (
Vx). In all, 154 men with matched age and body mass index were investigated that were divided into healthy fertile controls (n = 35), OAT men with
Vx (n = 55), OAT men without
Vx (n = 64). They were subjected to assessment of semen parameters, seminal levels of
testosterone (T),
androstenedione (A), 5α-androstane-3 α,17 β-diol (3 α-diol),
oestradiol (E2 ),
17-hydroxyprogesterone (17-OHP) and
progesterone (P). Seminal levels of T and A were significantly decreased where seminal levels of 3 α-diol, E2 , 17-OHP, P were significantly higher in OAT men with/without
Vx compared with fertile controls. Sperm count, sperm motility and sperm normal forms percentage demonstrated significant positive correlation with seminal T and A and significant negative correlation with seminal 3 α-diol, E2 , P. It is concluded that in fertile men, seminal T and A are significantly increased and seminal 3 α-diol, E2 , 17-OHP, P are significantly decreased compared with infertile OAT men with/without
Vx. Association of
Vx demonstrated a nonsignificant influence on these hormonal levels in OAT cases. Sperm count, sperm motility and sperm normal forms demonstrated significant positive correlation with seminal T, A and significant negative correlation with seminal 3 α-diol, E2 , P.