Prognostic factors in trabeculectomy with mitomycin C having history of previous glaucoma surgery.

Abstract

PURPOSE:

To evaluate the prognostic factors for surgical outcomes of subsequent trabeculectomy with mitomycin C (MMC) after prior incisional glaucoma surgery.

METHODS:

We reviewed medical records of a total cohort of 781 trabeculectomies with MMC, and selected 125 patients (125 eyes). The primary endpoints included persistent intraocular pressure (IOP) of ≥21 or <5 mmHg, the need for additional glaucoma surgery and deterioration of visual acuity to no light perception. Univariate and Multivariate analyses were performed by using the Cox proportional hazards model.

RESULTS:

The mean follow-up period was 26.8 months. The probabilities of success at 1, 2, and 3 years were 80.6, 72.2, and 70.6 %, respectively. Multivariate analysis showed that a shorter time interval between prior glaucoma surgery and subsequent trabeculectomy [relative risk (RR), 0.8867/year; P = 0.0090] and the number of prior trabeculectomies (RR, 2.2645; P = 0.0029) were significant prognostic factors for subsequent failure of trabeculectomy with MMC.

CONCLUSION:

A short time period between prior glaucoma surgery and subsequent trabeculectomy and the number of prior trabeculectomies are associated with surgical failure of subsequent trabeculectomy with MMC.

• Authors: Nanako Awai-Kasaoka, Toshihiro Inoue, Masaru Inatani, Yuji Takihara, Minako Ogata-Iwao, Hidenobu Tanihara
• Journal: Japanese journal of ophthalmology (Jpn J Ophthalmol) Vol. 57 Issue 6 Pg. 514-9 (Nov 2013) ISSN: 1613-2246 [Electronic] Japan
• PMID: 23912181 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Alkylating Agents
• Mitomycin

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Alkylating Agents (administration & dosage)
• Child
• Child, Preschool
• Female
• Glaucoma (diagnosis, physiopathology, surgery)
• Humans
• Infant
• Intraocular Pressure (physiology)
• Male
• Middle Aged
• Mitomycin (administration & dosage)
• Prognosis
• Retrospective Studies
• Risk Factors
• Tonometry, Ocular
• Trabeculectomy
• Treatment Failure
• Visual Acuity (physiology)