Abstract | OBJECTIVE: METHODS: Immunohistochemical assay was used to detect the expression of D2-40 and LVI in 107 ESCC patients. Then, the correlation between the clinicopathologic feature and the overall survival time of the patients was analyzed. RESULTS: The lymph node metastasis rates were 70% and 21% in the LVI-positive and LVI-negative groups, respectively. The nodal metastasis rate was higher in the LVI-positive group than in the LVI-negative group. Multivariate regression analysis showed that LVI was related to nodal metastasis (P<0.001). The median survival time of the patients was 26 and 43 months in the LVI-positive and LVI-negative groups, respectively. Although univariate regression analysis showed significant difference between the two groups (P=0.014), multivariate regression analysis revealed that LVI was not an independent prognostic factor for overall survival in the ESCC patients (P=0.062). Lymphatic node metastasis (P=0.031), clinical stage (P=0.019), and residual tumor (P=0.026) were the independent prognostic factors. CONCLUSION:
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Authors | Bing Bai, Wei Ma, Kai Wang, Sita Ha, Jian-Bo Wang, Bing-Xu Tan, Na-Na Wang, Sheng-Si Yang, Yi-Bin Jia, Yu-Feng Cheng |
Journal | Cancer biology & medicine
(Cancer Biol Med)
Vol. 10
Issue 2
Pg. 81-5
(Jun 2013)
ISSN: 2095-3941 [Print] China |
PMID | 23882422
(Publication Type: Journal Article)
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