Abstract | BACKGROUND/AIMS: METHODS: Adherence data from the Observational Study Saizen®-online, recorded with the easypod™ device collected between October 2009 and May 2011, were analyzed in pediatric patients receiving recombinant human growth hormone treatment for a variety of growth disorders. RESULTS: Data from 75 children (46 boys, 29 girls) with different growth disorders were analyzed over a period of 343 ± 201 (SD) days. Boys and girls showed similar mean ± SD adherence rates of 90.5 ± 3.1% and 92.2 ± 10.7%, respectively. Pubertal children (n = 41) had a significantly lower adherence rate (89.1 ± 13.7%) than prepubertal children (n = 29) (96.5 ± 3.9%; p < 0.005). There were nonsignificant differences in adherence rates according to diagnosis: growth hormone deficiency (n = 48) 91.4 ± 11.0%, small for gestational age (n = 18) 91.1 ± 15.3%, Turner syndrome (n = 6) 86.0 ± 14.5%, and chronic renal failure (n = 3) 99.3 ± 1.0%, although the latter two groups were small. CONCLUSION: Our data indicate that only a small number of pediatric patients using the easypod device had poor adherence to treatment. Further reliable adherence data are required to identify factors affecting long-term adherence in this population.
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Authors | Klaus Hartmann, Jochen Ittner, Elke Müller-Rossberg, Eckhard Schönau, Roger Stephan, K-Peter Ullrich, Bernd Hoppe, Rene Ramseger, Jürgen Brämswig |
Journal | Hormone research in paediatrics
(Horm Res Paediatr)
Vol. 80
Issue 1
Pg. 1-5
( 2013)
ISSN: 1663-2826 [Electronic] Switzerland |
PMID | 23860437
(Publication Type: Journal Article, Multicenter Study, Observational Study, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013 S. Karger AG, Basel. |
Chemical References |
- Recombinant Proteins
- Human Growth Hormone
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Topics |
- Adolescent
- Body Height
- Child
- Drug Delivery Systems
- Dwarfism, Pituitary
(drug therapy)
- Female
- Growth Disorders
(drug therapy)
- Human Growth Hormone
(administration & dosage, therapeutic use)
- Humans
- Male
- Patient Compliance
- Puberty
- Recombinant Proteins
(administration & dosage, therapeutic use)
- Turner Syndrome
(drug therapy)
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