CYP2B6*6 is associated with increased breast cancer risk.

Abstract

The cytochrome P450 2B6 (CYP2B6) is involved in the metabolism of testosterone. Functional changes in this enzyme may influence endogenous hormone exposure, which has been associated with risk of breast cancer. To assess potential associations between two functional polymorphisms CYP2B6_516_G>T (rs3745274) and CYP2B6_785_A>G (rs2279343) and breast cancer risk, we established a specific matrix-assisted laser desorption/ionization time-of-flight mass spectrometry assay. The GENICA breast cancer case-control study showed associations between the variant genotypes CYP2B6_516_TT and CYP2B6_785_GG and breast cancer risk with odds ratios (ORs) of 1.34 (p = 0.001) and 1.31 (p = 0.002), respectively. A similar effect was observed for carriers of the CYP2B6_516_T allele in a validation study including four independent studies from Germany, Sweden and USA. In a pooled analysis of all five studies involving 4,638 breast cancer cases and 3,594 controls of European ancestry, carriers of the CYP2B6_516_G and the CYP2B6_785_G variant had an increased breast cancer risk with ORs of 1.10 (p = 0.027) and 1.10 (p = 0.031), respectively. We conclude that the genetic variants CYP2B6_516_G and CYP2B6_785_G (designated CYP2B6*6), which are known to decrease activity of the CYP2B6 enzyme, contribute to an increased breast cancer risk.

• Authors: Christina Justenhoven, Daniela Pentimalli, Sylvia Rabstein, Volker Harth, Anne Lotz, Beate Pesch, Thomas Brüning, Thilo Dörk, Peter Schürmann, Natalia Bogdanova, Tjoung-Won Park-Simon, Fergus J Couch, Janet E Olson, Peter A Fasching, Matthias W Beckmann, Lothar Häberle, Arif Ekici, Per Hall, Kamilla Czene, Janjun Liu, Jingmei Li, Christian Baisch, Ute Hamann, Yon-Dschun Ko, Hiltrud Brauch
• Journal: International journal of cancer (Int J Cancer) Vol. 134 Issue 2 Pg. 426-30 (Jan 15 2014) ISSN: 1097-0215 [Electronic] United States
• PMID: 23824676 (Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: © 2013 UICC.

Chemical References

• Biomarkers, Tumor
• Aryl Hydrocarbon Hydroxylases
• CYP2B6 protein, human
• Cytochrome P-450 CYP2B6

Topics

• Adult
• Aged
• Aged, 80 and over
• Aryl Hydrocarbon Hydroxylases (genetics)
• Biomarkers, Tumor (genetics)
• Breast Neoplasms (etiology)
• Case-Control Studies
• Cytochrome P-450 CYP2B6
• Female
• Follow-Up Studies
• Genetic Predisposition to Disease
• Genotype
• Humans
• Meta-Analysis as Topic
• Middle Aged
• Polymorphism, Genetic (genetics)
• Prognosis
• Risk Factors
• Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization