Abstract | UNLABELLED: Research objective was to develop an algorithm of the recombinant activated Factor VII ( rFVIIa) prophylactic use for the bleeding implications prevention during central venous catheterization in Pediatric patients with acute leucosis and thrombocytopenia. METHODS: 30 Pediatric patients with acute leucosis and thrombocytopenia received rFVIIa 30-120 microg kg(-1) before the internal jugular vein catheterization with ultrasound control. Comparative group 1 included 39 Pediatric patients without preventive haemostatic treatment; comparative group 2 included 30 patients received platelet concentrate. RESULTS: the first attempt catheterization numbers increased, the time of the catheterization was reduced, platelet aggregation was improved and the bleeding implications frequency was 6.6% in patients received rFVIIa before the internal jugular vein catheterization. 23.1%--in the comparative group 1; 26.7% in the comparative group 2. CONCLUSION: Ultrasound navigation and rFVIIa preventive use together improve internal jugular vein catheterization results.
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Authors | A M Sergeeva, V A Mazurok, I I Zakirov, V A Kichigin |
Journal | Anesteziologiia i reanimatologiia
(Anesteziol Reanimatol)
2013 Jan-Feb
Issue 1
Pg. 18-21
ISSN: 0201-7563 [Print] Russia (Federation) |
PMID | 23808247
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Hemostatics
- Recombinant Proteins
- recombinant FVIIa
- Factor VIIa
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Topics |
- Adolescent
- Algorithms
- Catheterization, Central Venous
(adverse effects, methods)
- Child
- Child, Preschool
- Dose-Response Relationship, Drug
- Factor VIIa
(therapeutic use)
- Hemorrhage
(etiology, prevention & control)
- Hemostatics
(therapeutic use)
- Humans
- Infant
- Jugular Veins
- Leukemia
(complications)
- Platelet Aggregation
(drug effects)
- Platelet Transfusion
- Recombinant Proteins
(therapeutic use)
- Thrombocytopenia
(complications)
- Time Factors
- Ultrasonography, Interventional
(methods)
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