Behavioral effects of long-term antimuscarinic use in patients with spinal dysraphism: a case control study.

Abstract

PURPOSE:

We explored possible associations between long-term antimuscarinic use and behavioral problems in children with spinal dysraphism and neurogenic bladder.

MATERIALS AND METHODS:

Children with open and closed spinal dysraphism were recruited from 2 pediatric hospitals, 1 in Amsterdam and 1 in Utrecht, The Netherlands. At the Amsterdam facility antimuscarinics were prescribed in selected patients with detrusor overactivity. At the Utrecht facility antimuscarinics were prescribed from birth onward in patients with spinal dysraphism beginning in the early 1990s. Parents of study participants were asked to fill out a Child Behavior Checklist. Demographics, data on level and type(s) of lesion, and presence of hydrocephalus with a drain (and, if applicable, number of drain revisions) were retrieved for each patient. Cases and controls (8 boys and 8 girls per group) were matched on a 1-to-1 basis.

RESULTS:

Data on 32 children were analyzed. Median age was 10.6 years in cases and 10.5 years in controls (p=0.877). In each group 9 of 16 patients had hydrocephalus with a drain. No significant difference in Child Behavior Checklist scores for total problems was found between cases and controls (median 52.0 vs 59.5, p=0.39). No differences were found between the groups on any subdomain of the Child Behavior Checklist.

CONCLUSIONS:

No significant differences in behavior were found between children with spinal dysraphism with and without long-term use of antimuscarinics.

• Authors: Paul W Veenboer, Jaap Huisman, Rafal J Chrzan, Caroline F Kuijper, Pieter Dik, Laetitia M O de Kort, Tom P V M de Jong
• Journal: The Journal of urology (J Urol) Vol. 190 Issue 6 Pg. 2228-32 (Dec 2013) ISSN: 1527-3792 [Electronic] United States
• PMID: 23792150 (Publication Type: Journal Article)
• Copyright: Copyright © 2013 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

Chemical References

• Mandelic Acids
• Muscarinic Antagonists
• oxybutynin

Topics

• Adolescent
• Case-Control Studies
• Child
• Child Behavior (drug effects)
• Child Behavior Disorders (chemically induced)
• Female
• Humans
• Male
• Mandelic Acids (adverse effects, pharmacology, therapeutic use)
• Muscarinic Antagonists (adverse effects, pharmacology, therapeutic use)
• Spinal Dysraphism (complications)
• Time Factors
• Urinary Bladder, Neurogenic (drug therapy, etiology)