Antiproliferative Homoisoflavonoids and Bufatrienolides from Urginea depressa.

Abstract

Investigation of the South African plant Urginea depressa Baker (Asparagaceae Juss.) for antiproliferative activity against the A2780 ovarian cancer cell line led to the isolation of the six new homoisoflavonoids urgineanins A-F (1-6), the two known bufatrienolides 7 and 9, and the new bufatrienolides urginins B and C (8 and 10). Structures were elucidated based on analysis of their 1D and 2D NMR spectra, electronic circular dichroism, and mass spectrometric data. Five of the six new homoisoflavonoids had good antiproliferative activity against the A2780 ovarian cancer, A2058 melanoma, and H522-T1 human non-small-cell lung cancer cells, and urgineanin A (1) had submicromolar activity against all three cell lines. The four bufatrienolides 7-10 had strong antiproliferative activity against the same cell line, with IC50 values of 24.1, 11.2, 111, and 40.6 nM, respectively.

• Authors: Yumin Dai, Liva Harinantenaina, Peggy J Brodie, Michael Goetz, Yongchun Shen, Karen TenDyke, David G I Kingston
• Journal: Journal of natural products (J Nat Prod) Vol. 76 Issue 5 Pg. 865-72 (May 24 2013) ISSN: 1520-6025 [Electronic] United States
• PMID: 23659371 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Antineoplastic Agents, Phytogenic
• Isoflavones
• Steroids
• urgineanin A

Topics

• Antineoplastic Agents, Phytogenic (chemistry, isolation & purification, pharmacology)
• Drimia (chemistry)
• Drug Screening Assays, Antitumor
• Female
• Humans
• Inhibitory Concentration 50
• Isoflavones (chemistry, isolation & purification, pharmacology)
• Molecular Structure
• Nuclear Magnetic Resonance, Biomolecular
• Steroids (chemistry, isolation & purification, pharmacology)