High fat diet partially attenuates fermentation responses in rats fed resistant starch from high-amylose maize.

Abstract

OBJECTIVE:

The effects of type 2 resistant starch from high-amylose maize (HAM-RS2) in rodents fed with low-fat diets were demonstrated in previous studies. Fish oil is also reported to reduce body fat. In the current study, the effects of high fat and fish oil on HAM-RS2 feeding in rats were investigated.

DESIGN AND METHODS:

Rats were fed 0 or 27% (weight) HAM-RS2 with low (15% energy) or high fat (42% energy) diets that included 0 or 10% (energy) tuna oil to test the effect of HAM-RS2 in diet-induced obesity and effects of tuna oil. Data were analyzed as 2 × 2 × 2 factorial.

RESULTS:

Rats fed HAM-RS2 had decreased cecal contents pH, increased cecal and cecal contents weight, increased cecal contents acetate, propionate, and butyrate, increased GLP-1 and PYY, and decreased abdominal fat. However, high fat partially attenuated effects of HAM-RS2, but increased GLP-1 active. Dietary tuna oil had limited effects at concentration used.

CONCLUSIONS:

Results demonstrated that a high fat diet partially attenuates the response to HAM-RS2. The mechanism may center on reduced levels of cecal contents propionate and butyrate and reduced serum PYY. This study demonstrated that with consumption of high fat, HAM-RS2 produces fermentation but results in partial attenuation of effects.

• Authors: Jason A Charrier, Roy J Martin, Kathleen L McCutcheon, Anne M Raggio, Felicia Goldsmith, M'famara Goita, Reshani N Senevirathne, Ian L Brown, Christine Pelkman, June Zhou, John Finley, Holiday A Durham, Michael J Keenan
• Journal: Obesity (Silver Spring, Md.) (Obesity (Silver Spring)) Vol. 21 Issue 11 Pg. 2350-5 (Nov 2013) ISSN: 1930-739X [Electronic] United States
• PMID: 23512798 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 The Obesity Society.

Chemical References

• Dietary Fats
• Starch
• Amylose

Topics

• Abdominal Fat (anatomy & histology)
• Amylose (metabolism)
• Animals
• Body Weight (drug effects)
• Diet, High-Fat
• Dietary Fats (pharmacology)
• Eating (physiology)
• Energy Intake (physiology)
• Fermentation (drug effects)
• Male
• Rats
• Rats, Sprague-Dawley
• Starch (metabolism)
• Zea mays (metabolism)