Plasma viremia and cellular HIV-1 DNA persist despite autologous hematopoietic stem cell transplantation for HIV-related lymphoma.

Abstract

A cure of HIV-1 has been achieved in one individual through allogeneic stem cell transplantation with a CCR5[INCREMENT]32 homozygous donor. Whether myeloablation and autologous stem cell transplantation for lymphoma in patients on suppressive antiretroviral therapy can eliminate HIV-1 reservoirs is unknown. Low-level plasma viremia and total HIV-1 DNA and 2-LTR circles in blood mononuclear cells were quantified after autologous transplantation in 10 patients on suppressive antiretroviral therapy using quantitative polymerase chain reaction assays capable of single-copy nucleic acid detection. Plasma viremia was detectable in 9 patients, whereas HIV-1 DNA was detectable in all 10 patients, indicating that HIV-1 had not been eliminated.

• Authors: Anthony R Cillo, Amrita Krishnan, Ronald T Mitsuyasu, Deborah K McMahon, Shirley Li, John J Rossi, John A Zaia, John W Mellors
• Journal: Journal of acquired immune deficiency syndromes (1999) (J Acquir Immune Defic Syndr) Vol. 63 Issue 4 Pg. 438-41 (Aug 01 2013) ISSN: 1944-7884 [Electronic] United States
• PMID: 23493152 (Publication Type: Journal Article, Multicenter Study, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Retroviral Agents
• DNA, Viral
• Myeloablative Agonists
• RNA, Viral

Topics

• Adult
• Anti-Retroviral Agents (therapeutic use)
• Cross-Sectional Studies
• DNA, Viral (blood)
• HIV Long Terminal Repeat
• HIV-1
• Hematopoietic Stem Cell Transplantation
• Humans
• Leukocytes, Mononuclear
• Lymphoma, AIDS-Related (blood, therapy, virology)
• Male
• Middle Aged
• Myeloablative Agonists (therapeutic use)
• RNA, Viral (blood)
• Transplantation, Autologous
• Viral Load
• Young Adult