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A powerful molecular synergy between mutant Nucleophosmin and Flt3-ITD drives acute myeloid leukemia in mice.

AuthorsA Mupo, L Celani, O Dovey, J L Cooper, C Grove, R Rad, P Sportoletti, B Falini, A Bradley, G S Vassiliou
JournalLeukemia (Leukemia) Vol. 27 Issue 9 Pg. 1917-20 (Sep 2013) ISSN: 1476-5551 [Electronic] England
PMID23478666 (Publication Type: Letter, Research Support, Non-U.S. Gov't)
Chemical References
  • Nuclear Proteins
  • Nucleophosmin
  • Flt3 protein, mouse
  • fms-Like Tyrosine Kinase 3
Topics
  • Animals
  • Cell Transformation, Neoplastic (genetics)
  • Disease Models, Animal
  • Epistasis, Genetic
  • Leukemia, Myeloid, Acute (genetics, metabolism)
  • Mice
  • Mice, Knockout
  • Mutation
  • Nuclear Proteins (genetics, metabolism)
  • Nucleophosmin
  • Tandem Repeat Sequences
  • fms-Like Tyrosine Kinase 3 (genetics, metabolism)

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