Abstract |
The essential oil from Cedrelopsis grevei leaves, an aromatic and medicinal plant from Madagascar, is widely used in folk medicine. Essential oil was characterized by GC-MS and quantified by GC-FID. Sixty-four components were identified. The major constituents were: (E)-β- farnesene (27.61%), δ-cadinene (14.48%), α-copaene (7.65%) and β- elemene (6.96%). The essential oil contained a complex mixture consisting mainly sesquiterpene hydrocarbons (83.42%) and generally sesquiterpenes (98.91%). The essential oil was tested cytotoxic (on human breast cancer cells MCF-7), antimalarial (Plasmodium falciparum), antiinflammatory and antioxidant ( ABTS and DPPH assays) activities. C. grevei essential oil was active against MCF-7 cell lines (IC50=21.5 mg/L), against P. falciparum, (IC50=17.5mg/L) and antiinflammatory (IC50=21.33 mg/L). The essential oil exhibited poor antioxidant activity against DPPH (IC50>1000 mg/L) and ABTS (IC50=110 mg/L) assays. A bibliographical review was carried out of all essential oils identified and tested with respect to antiplasmodial, anticancer and antiinflammatory activities. The aim was to establish correlations between the identified compounds and their biological activities (antiplasmodial, anticancer and antiinflammatory). According to the obtained correlations, 1,4-cadinadiene (R(2)=0.61) presented a higher relationship with antimalarial activity. However, only (Z)-β- farnesene (R(2)=0.73) showed a significant correlation for anticancer activity.
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Authors | Samia Afoulous, Hicham Ferhout, Emmanuel Guy Raoelison, Alexis Valentin, Béatrice Moukarzel, François Couderc, Jalloul Bouajila |
Journal | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
(Food Chem Toxicol)
Vol. 56
Pg. 352-62
(Jun 2013)
ISSN: 1873-6351 [Electronic] England |
PMID | 23459148
(Publication Type: Journal Article)
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Copyright | Copyright © 2013 Elsevier Ltd. All rights reserved. |
Chemical References |
- Anti-Inflammatory Agents
- Antimalarials
- Antineoplastic Agents, Phytogenic
- Antioxidants
- Oils, Volatile
- Plant Extracts
- Sesquiterpenes
- beta-farnesene
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Topics |
- Anti-Inflammatory Agents
(chemistry, pharmacology)
- Antimalarials
(chemistry, pharmacology)
- Antineoplastic Agents, Phytogenic
(chemistry, pharmacology)
- Antioxidants
(chemistry, pharmacology)
- Female
- Gas Chromatography-Mass Spectrometry
- Humans
- Inhibitory Concentration 50
- MCF-7 Cells
- Madagascar
- Oils, Volatile
(chemistry, pharmacology)
- Plant Extracts
(chemistry, pharmacology)
- Plant Leaves
(chemistry)
- Plants, Medicinal
(chemistry)
- Plasmodium falciparum
(drug effects)
- Rutaceae
(chemistry)
- Sesquiterpenes
(chemistry, pharmacology)
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