Abstract | AIMS:
Silver stainable nucleolar organizer regions ( AgNORs) have received a great deal of attention recently as their frequency within the nuclei is significantly higher in malignant cells than in normal, reactive or benign neoplastic cells. The objective of this study was to carry out a quantitative assessment of large and small AgNORs in oral normal mucosa, precancerous lesions and infiltrating squamous cell carcinomas. METHODS: The study comprised 110 formalin-fixed, paraffin-embedded oral mucosal biopsies consisting of 30 oral dysplasia, 60 oral squamous cell carcinomas and 20 normal oral mucosa. AgNORs were counted in each nucleus, categorized as small, large and total number of AgNORs in each cell and their means were calculated. RESULTS: CONCLUSIONS: By combining both the enumeration of AgNORs and their size, good distinction can be made between normal, dysplastic and infiltrating squamous cell carcinomas. This could help in the early diagnosis and prognosis of dysplastic mucosal lesions and their malignant transformation.
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Authors | Aman Chowdhry, Revati Shailesh Deshmukh, Deepika Shukla, Deepika Bablani, Shashwat Mishra |
Journal | Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia
(Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub)
Vol. 158
Issue 2
Pg. 282-7
(Jun 2014)
ISSN: 1804-7521 [Electronic] Czech Republic |
PMID | 23446205
(Publication Type: Journal Article)
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Chemical References |
- Coloring Agents
- Silver Nitrate
|
Topics |
- Adult
- Aged
- Carcinoma, Squamous Cell
(pathology)
- Coloring Agents
- Female
- Humans
- Male
- Middle Aged
- Mouth Mucosa
(pathology)
- Mouth Neoplasms
(pathology)
- Nucleolus Organizer Region
(pathology)
- Precancerous Conditions
(pathology)
- Silver Nitrate
- Young Adult
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