Structure, function and regulation of CSB: a multi-talented gymnast.

Abstract

The Cockayne syndrome complementation group B protein, CSB, plays pivotal roles in transcription regulation and DNA repair. CSB belongs to the SNF2/SWI2 ATP-dependent chromatin remodeling protein family, and studies from many laboratories have revealed that CSB has multiple activities and modes of regulation. To understand the underlying mechanisms of Cockayne syndrome, it is necessary to understand how the biochemical activities of CSB are used to carry out its biological functions. In this review, we summarize our current knowledge of the structure, function and regulation of CSB, and discuss how these properties can impact the biological functions of this chromatin remodeler.

• Authors: Robert J Lake, Hua-Ying Fan
• Journal: Mechanisms of ageing and development (Mech Ageing Dev) 2013 May-Jun Vol. 134 Issue 5-6 Pg. 202-11 ISSN: 1872-6216 [Electronic] Ireland
• PMID: 23422418 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
• Copyright: Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Poly-ADP-Ribose Binding Proteins
• DNA Helicases
• ERCC6 protein, human
• DNA Repair Enzymes

Topics

• Animals
• Chromatin Assembly and Disassembly (physiology)
• DNA Helicases (chemistry, genetics, metabolism)
• DNA Repair (physiology)
• DNA Repair Enzymes (chemistry, genetics, metabolism)
• Humans
• Poly-ADP-Ribose Binding Proteins
• Structure-Activity Relationship
• Transcription, Genetic (physiology)