Abstract | OBJECTIVE: METHODS: RESULTS: Compared with the PAH group ((37 ± 5) mm Hg (1 mm Hg = 0.133 kPa), 45.5% ± 5.5%), the mPAP and WT% of the high-dose ((27 ± 4) mm Hg, 13.1% ± 3.9%) and low-dose ((28 ± 4) mm Hg, 16.7% ± 1.7%) rosiglitazone intervention group were significantly lower (P < 0.01), but were still higher than those of the control group ((17 ± 3) mm Hg, 8.9% ± 2.3%) (P < 0.05 or P < 0.01). The perivascular inflammation score and levels of IL-6, TNF-α, MCP-1 of high-dose and low-dose rosiglitazone intervention groups were significantly lower than those of the PAH group (P < 0.01). Compared with the low-dose rosiglitazone intervention group, all the above indices of the high-dose rosiglitazone intervention group appeared much lower (P > 0.05). CONCLUSION:
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Authors | Xiao-fang Wang, Wei-xuan Lu, Jun Guo, Guo Li, Yun-jian Zhang |
Journal | Zhonghua yi xue za zhi
(Zhonghua Yi Xue Za Zhi)
Vol. 92
Issue 30
Pg. 2144-7
(Aug 14 2012)
ISSN: 0376-2491 [Print] China |
PMID | 23158281
(Publication Type: Journal Article)
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Chemical References |
- Thiazolidinediones
- Rosiglitazone
- Monocrotaline
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Topics |
- Animals
- Hypertension, Pulmonary
(chemically induced, pathology, physiopathology)
- Inflammation
(metabolism)
- Male
- Monocrotaline
(adverse effects)
- Pulmonary Artery
(pathology)
- Rats
- Rats, Sprague-Dawley
- Rosiglitazone
- Thiazolidinediones
(pharmacology)
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