Treatment of ulcerative necrobiosis lipoidica with topical calcineurin inhibitor: case report and literature review.

Abstract

BACKGROUND:

Ulcerative necrobiosis lipoidica (UNL) is an uncommon disease, which is frequently recalcitrant to available therapies. It is characterized by well-defined, ulcerated plaques with indurated borders and atrophic centers. Multiple therapeutic options have been described, with variable success rates.

OBJECTIVE:

To report the efficacy of using topical tacrolimus in treating UNL.

METHOD:

Topical tacrolimus was used in the treatment of two patients with UNL.

RESULT:

Topical tacrolimus is effective in treating UNL.

CONCLUSION:

Topical tacrolimus is a reasonably effective choice in treating UNL.

• Authors: Yousef Binamer, Laura Sowerby, Therese El-Helou
• Journal: Journal of cutaneous medicine and surgery (J Cutan Med Surg) 2012 Nov-Dec Vol. 16 Issue 6 Pg. 458-61 ISSN: 1203-4754 [Print] United States
• PMID: 23149208 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• Calcineurin Inhibitors
• Immunosuppressive Agents
• Tacrolimus

Topics

• Administration, Cutaneous
• Adult
• Aged, 80 and over
• Calcineurin Inhibitors
• Female
• Humans
• Immunosuppressive Agents (administration & dosage, therapeutic use)
• Necrobiosis Lipoidica (complications, drug therapy)
• Skin Ulcer (complications, drug therapy)
• Tacrolimus (administration & dosage, therapeutic use)