Mitigation of oxidative damage by green tea polyphenols and Tai Chi exercise in postmenopausal women with osteopenia.

Abstract

BACKGROUND:

Osteoporosis is a degenerative bone disease predominantly in postmenopausal women. Green tea polyphenols (GTP) and Tai Chi (TC) have been shown to be beneficial on human bone health. This study examined the efficacy of GTP and TC on mitigation of oxidative damage in postmenopausal women with osteopenia.

METHODS:

A 6-month randomized and placebo-controlled clinical trial was conducted in 171 postmenopausal women with osteopenia, who were recruited from Lubbock County, Texas. These participants were treated with placebo, GTP (500 mg daily), placebo + TC (60-minute group exercise, 3 times/week), or GTP (500 mg daily) + TC (60-minute group exercise, 3 times/week), respectively. Their blood and urine samples were collected at the baseline, 1-, 3- and 6-months during intervention for assessing levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG), an oxidative DNA damage biomarker, and concentrations of serum and urine GTP components.

RESULTS:

The elevated concentrations of serum and urinary GTP components demonstrated a good adherence for the trial. A significant reduction of urinary 8-OHdG concentrations was found in all three treated groups during 3-month (P<0.001) and 6-month (P<0.001) intervention, as compared to the placebo group. The significant time- and dose-effects on mitigation of the oxidative damage biomarker were also found for GTP, TC, and GTP+TC intervened groups.

CONCLUSION:

Our study demonstrated that GTP and TC interventions were effective strategies of reducing the levels of oxidative stress, a putative mechanism for osteoporosis in postmenopausal women, and more importantly, working in an additive manner, which holds the potential as alternative tools to improve bone health in this population.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT00625391.

• Authors: Guoqing Qian, Kathy Xue, Lili Tang, Franklin Wang, Xiao Song, Ming-Chien Chyu, Barbara C Pence, Chwan-Li Shen, Jia-Sheng Wang
• Journal: PloS one (PLoS One) Vol. 7 Issue 10 Pg. e48090 ( 2012) ISSN: 1932-6203 [Electronic] United States
• PMID: 23118932 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural)

Chemical References

• Biomarkers
• Bone Density Conservation Agents
• Plant Extracts
• Polyphenols
• 8-Hydroxy-2'-Deoxyguanosine
• Deoxyguanosine

Topics

• 8-Hydroxy-2'-Deoxyguanosine
• Aged
• Biomarkers (urine)
• Bone Density Conservation Agents (administration & dosage, pharmacokinetics)
• Bone Diseases, Metabolic (therapy, urine)
• Camellia sinensis
• Combined Modality Therapy
• DNA Damage
• Deoxyguanosine (analogs & derivatives, urine)
• Female
• Humans
• Middle Aged
• Oxidative Stress
• Phytotherapy
• Plant Extracts (administration & dosage, pharmacokinetics)
• Polyphenols (administration & dosage, pharmacokinetics)
• Postmenopause
• Tai Ji
• Treatment Outcome