Abstract |
Vitamin D has been investigated in association with cognitive function in older adults. It is unclear whether hypovitaminosis D could be associated with Alzheimer's disease (AD). Our objective was to systematically review and quantitatively synthesize the association of low serum 25-hydroxyvitamin D (25OHD) concentrations with AD in adults. A Medline and PsycINFO® search was conducted on May 2012, with no limit of date, using the MeSH terms " Vitamin D" OR " Hydroxycholecalciferols" combined with the MeSH terms " Alzheimer disease" OR " Dementia" OR "Cognition" OR " Cognition disorders" OR "Memory" OR " Memory Disorders" OR "Executive Function" OR "Attention" OR "Neuropsychological Tests". Of the 284 selected studies, 10 observational studies (including 9 case-controls and 1 cohort study) met the selection criteria. All were of good quality. The number of AD cases ranged from 20 to 211 (40%-100% female). Finally, 7 case-control studies were eligible for fixed and random-effects meta-analyses of bias-corrected effect size of the difference in serum 25OHD concentrations between AD cases and controls using an inverse-variance method. The pooled effect size in random-effects meta-analysis was 1.40 (95% CI: 0.26;2.54), a 'large' effect size that indicates that serum 25OHD concentrations were 1.4 standard deviation units lower in AD cases compared to cognitively healthy controls (p = 0.016). In conclusion, AD cases had lower serum vitamin D concentrations than matched controls. This reinforces the conceptualization of vitamin D as a ' neurosteroid hormone' and as a potential biomarker of AD.
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Authors | Cedric Annweiler, David J Llewellyn, Olivier Beauchet |
Journal | Journal of Alzheimer's disease : JAD
(J Alzheimers Dis)
Vol. 33
Issue 3
Pg. 659-74
( 2013)
ISSN: 1875-8908 [Electronic] Netherlands |
PMID | 23042216
(Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)
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Chemical References |
- Vitamin D
- 25-hydroxyvitamin D
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Topics |
- Alzheimer Disease
(blood, complications)
- Cognition Disorders
(blood, etiology)
- Humans
- MEDLINE
(statistics & numerical data)
- Vitamin D
(analogs & derivatives, blood)
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