Abstract | BACKGROUND: METHODS: A retrospective 10-year review at a tertiary medical center identified 100 patients with Ogilvie's syndrome, in whom treatment course and clinical and radiographic response were evaluated. RESULTS: Colonoscopy was significantly more successful than neostigmine (defined as no further therapy) after 1 or 2 interventions (75.0% vs 35.5%, P = .0002, and 84.6% vs 55.6%, P = .0031, respectively). One colonoscopy was more effective than 2 neostigmine administrations (75.0% vs 55.6%, P = .044). Clinical response (poor, fair, or good) was significantly better after colonoscopy than neostigmine after 1 or 2 interventions (P = .0028 and P = .00079). Cecal diameters decreased significantly more after colonoscopy than neostigmine (from 10.2 ± .5 cm to 7.1 ± .4 cm vs from 10.5 ± .5 cm to 8.8 ± .5 cm, P = .026). Neostigmine administration before colonoscopy did not affect outcomes. There were 3 perforations (3.7%): 1 each after colonoscopy, neostigmine, and no intervention. Neostigmine dose or repetition did not affect radiographic (P = .41) or clinical (P = .31) response. CONCLUSIONS:
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Authors | Victor B Tsirline, Alla Y Zemlyak, Michael J Avery, Paul D Colavita, Ashley B Christmas, B Todd Heniford, Ronald F Sing |
Journal | American journal of surgery
(Am J Surg)
Vol. 204
Issue 6
Pg. 849-55; discussion 855
(Dec 2012)
ISSN: 1879-1883 [Electronic] United States |
PMID | 23021196
(Publication Type: Comparative Study, Evaluation Study, Journal Article)
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Copyright | Copyright © 2012 Elsevier Inc. All rights reserved. |
Chemical References |
- Cholinesterase Inhibitors
- Neostigmine
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Topics |
- Cecum
(diagnostic imaging, pathology)
- Cholinesterase Inhibitors
(therapeutic use)
- Colonic Pseudo-Obstruction
(complications, therapy)
- Colonoscopy
- Combined Modality Therapy
- Drug Administration Schedule
- Female
- Humans
- Intestinal Perforation
(etiology)
- Linear Models
- Logistic Models
- Male
- Middle Aged
- Multivariate Analysis
- Neostigmine
(therapeutic use)
- Radiography
- Retrospective Studies
- Treatment Outcome
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