Abstract | OBJECTIVE: DESIGN: This study was designed as a prospective, randomized-controlled, and single-blinded clinical trial. Twenty-seven patients with clinical and radiologic evidence of knee osteoarthritis were randomly assigned into two groups and were treated with mature mud packs (n 15) or hot packs (n=12). Patients were evaluated for pain [based on the visual analog scale (VAS)], function (WOMAC, 6 min walking distance), quality of life [Short Form-36 (SF-36)], and serum levels of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and insulin-like growth factor-1 (IGF-1) at baseline, post-treatment, and 3 and 6~months after treatment. RESULTS: The mud pack group shows a significant improvement in VAS, pain, stifness, and physical function domains of WOMAC. The difference between groups of pain and physical activity domains is significant at post-treatment in favor of mud pack. For a 6 min walking distance, mud pack shows significant improvement, and the difference is significant between groups in favor of mud pack at post-treatment and 3 and 6 months after treatment. Mud pack shows significant improvement in the pain subscale of SF-36 at the third month continuing until the sixth month after the treatment. Significant improvements are found for the social function, vitality/energy, physical role disability, and general health subscales of SF-36 in favor of the mud pack compared with the hot pack group at post-treatment. A significant increase is detected for IGF-1 in the mud pack group 3 months after treatment compared with the baseline, and the difference is significant between groups 3 months after the treatment. CONCLUSION:
Mud pack is a favorable option compared with hotpack for pain relief and for the improvement of functional conditions in treating patients with knee osteoarthritis.
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Authors | Ayşe Sarsan, Nuray Akkaya, Merih Ozgen, Necmettin Yildiz, Nilgun Simsir Atalay, Fusun Ardic |
Journal | Journal of back and musculoskeletal rehabilitation
(J Back Musculoskelet Rehabil)
Vol. 25
Issue 3
Pg. 193-9
( 2012)
ISSN: 1878-6324 [Electronic] Netherlands |
PMID | 22935858
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Interleukin-6
- Tumor Necrosis Factor-alpha
- Insulin-Like Growth Factor I
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Topics |
- Humans
- Hyperthermia, Induced
(methods)
- Insulin-Like Growth Factor I
(metabolism)
- Interleukin-6
(blood)
- Middle Aged
- Mud Therapy
(methods)
- Osteoarthritis, Knee
(blood, physiopathology, therapy)
- Pain Management
(methods)
- Pain Measurement
- Prospective Studies
- Quality of Life
- Single-Blind Method
- Treatment Outcome
- Tumor Necrosis Factor-alpha
(blood)
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