Abstract |
Oromucosal midazolam (Buccolam™), a benzodiazepine, is approved in the EU for the treatment of paediatric patients (aged 3 months to <18 years) with acute, prolonged, convulsive seizures. In clinical trials in children with prolonged, acute, convulsive seizures, oromucosal midazolam was at least as effective as rectal diazepam and as effective as intravenous diazepam in the treatment of seizures and was generally well tolerated. It has several advantages over rectal diazepam, the previous gold standard of treatment, such as having a more convenient and socially acceptable administration route.
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Authors | Lesley J Scott, Katherine A Lyseng-Williamson, Karly P Garnock-Jones |
Journal | CNS drugs
(CNS Drugs)
Vol. 26
Issue 10
Pg. 893-7
(Oct 01 2012)
ISSN: 1179-1934 [Electronic] New Zealand |
PMID | 22928704
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Administration, Buccal
- Adolescent
- Child
- Child, Preschool
- Diazepam
(administration & dosage)
- Humans
- Infant
- Midazolam
(administration & dosage, adverse effects)
- Seizures
(drug therapy)
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