Activity of short lipopeptides and conventional antimicrobials against planktonic cells and biofilms formed by clinical strains of Staphylococcus aureus.

Abstract

BACKGROUND:

The therapy for staphylococcal skin diseases is facing several difficulties caused by the growth of biofilms and development of resistant strains. Short synthetic lipopeptides designed on the basis of antimicrobial peptide structure seem to provide an alternative to conventional therapy. The purpose of this study was to synthesize a group of lipopeptides and evaluate their antistaphylococcal activity against biofilms formed by clinical strains of Staphylococcus aureus.

RESULTS:

The compounds exhibited a strong antibiofilm activity against all the isolates. The maturity of the biofilms has shown a well-defined influence on antimicrobial activity of conventional antimicrobials.

DISCUSSION:

Results showed that the lipopeptides were promising agents as the time of the culture did not greatly affect their activity.

• Authors: Malgorzata Dawgul, Wioletta Baranska-Rybak, Elzbieta Kamysz, Anna Karafova, Roman Nowicki, Wojciech Kamysz
• Journal: Future medicinal chemistry (Future Med Chem) Vol. 4 Issue 12 Pg. 1541-51 (Aug 2012) ISSN: 1756-8927 [Electronic] England
• PMID: 22917244 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Infective Agents
• Lipopeptides

Topics

• Anti-Infective Agents (pharmacology, therapeutic use)
• Biofilms (drug effects)
• Humans
• Lipopeptides (chemical synthesis, pharmacology, therapeutic use)
• Microbial Sensitivity Tests
• Quorum Sensing (drug effects)
• Skin Diseases (drug therapy, microbiology)
• Staphylococcal Infections (drug therapy, microbiology)
• Staphylococcus aureus (drug effects, isolation & purification, physiology)