Abstract | PURPOSE OF REVIEW:
Artesunate treatment reduces mortality in severe malaria when compared with quinine. Nevertheless, severe malaria is associated with mortality rates between 1.4 and 9.5% after hospitalization. This review puts into context the recent developments in understanding the pathophysiology of malaria and how these may be reflected in renewed attempts at improving adjunct therapies. Identifying new adjunct approaches has been particularly difficult for severe malaria because most interventions have either caused harm or failed to confer benefit. RECENT FINDINGS: SUMMARY: Outcomes with adjunct therapies for severe malaria have been poor, but as insights into pathophysiological processes are deepened it may be possible eventually to reduce mortality further.
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Authors | Sanjeev Krishna |
Journal | Current opinion in infectious diseases
(Curr Opin Infect Dis)
Vol. 25
Issue 5
Pg. 484-8
(Oct 2012)
ISSN: 1473-6527 [Electronic] United States |
PMID | 22907277
(Publication Type: Journal Article, Review)
|
Chemical References |
- Antimalarials
- Artemisinins
- Nitric Oxide
- Artesunate
|
Topics |
- Antimalarials
(administration & dosage)
- Artemisinins
(administration & dosage)
- Artesunate
- Blood Transfusion
(methods)
- Fluid Therapy
(methods)
- Humans
- Malaria
(therapy)
- Malaria, Cerebral
(diagnosis, therapy)
- Nitric Oxide
(administration & dosage)
|