[Contents of 6-keto-prostaglandin F1 alpha and thromboxane B2 in the blood of patients with bronchial asthma].

Abstract

There is a relationship between severity of bacterial bronchial asthma clinical symptoms and plasma 6-keto-PGF1 alpha, TxB2: in moderate disease against grave one as well as in clinical versus subclinical forms (remission) relevant indices are reduced. On the one hand elevated content of blood 6-keto-PGF1 alpha seems compensatory rising in response to TxB2 bronchoconstriction. On the other hand, it impairs microcirculation and enhances mediators of inflammation, promotes exudation and edema of bronchoalveolar mucosa, thus contributing to obstruction.

• Authors: L G Grigorian, T A Chervinskaia
• Journal: Klinicheskaia meditsina (Klin Med (Mosk)) Vol. 68 Issue 11 Pg. 26-7 (Nov 1990) ISSN: 0023-2149 [Print] Russia (Federation)
• Vernacular Title: Soderzhanie 6-keto-prostaglandina F1 alfa i tromboksana B2 v krovi bol'nykh bronkhial'noĭ astmoĭ.
• PMID: 2283804 (Publication Type: English Abstract, Journal Article)

Chemical References

• Thromboxane B2
• 6-Ketoprostaglandin F1 alpha

Topics

• 6-Ketoprostaglandin F1 alpha (blood)
• Adolescent
• Adult
• Asthma (blood, physiopathology)
• Bronchi (physiopathology)
• Constriction, Pathologic
• Female
• Humans
• Male
• Microcirculation
• Middle Aged
• Thromboxane B2 (blood)