Contribution of capsule endoscopy to Peutz-Jeghers syndrome management in children.

Abstract

BACKGROUND:

Capsule endoscopy is recommended for children with Peutz-Jeghers syndrome as young as 8 years of age. Aim of our study was to evaluate the contribution of capsule endoscopy in managing risk of further obstructive complications.

METHODS:

A retrospective analysis of 27 children who received at least 1 capsule endoscopy was conducted. Peutz-Jeghers syndrome was diagnosed based on the presence of an STK11 gene mutation or on the association of a hamartoma with 2 of 3 criteria (family history, mucocutaneous pigmentation, small bowel polyposis).

RESULTS:

Thirty-seven capsule endoscopies were performed in 27 patients. The median age at first endoscopy was 11.4 years (range, 5.4-20.9). Jejunal polyps were found in 72% and ileal polyps in 55% of capsules. The original recommendations were followed 20/30 times. Three gastroscopies, 4 colonoscopies, 7 double balloon enteroscopies and 1 intra-operative enteroscopy were performed after the capsules. These procedures revealed jejunal polyps in 9/9 cases (8/9 resected) and ileal polyps in 3/5 (all resected). One intussusception occurred 8.4 months after the capsule endoscopy and required surgical resection.

CONCLUSION:

Capsule endoscopy is easily feasible in Peutz Jeghers syndrome, but the practice of systematic and repeated procedures needs to be validated prospectively.

• Authors: Swellen Gastineau, Jérôme Viala, Dominique Caldari, Emmanuel Mas, Estelle Darviot, Catherine Le Gall, Chantal Maurage, Laurent Michaud, Alain Dabadie
• Journal: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver (Dig Liver Dis) Vol. 44 Issue 10 Pg. 839-43 (Oct 2012) ISSN: 1878-3562 [Electronic] Netherlands
• PMID: 22795616 (Publication Type: Journal Article)
• Copyright: Copyright © 2012 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

Topics

• Adolescent
• Capsule Endoscopy
• Child
• Child, Preschool
• Female
• Follow-Up Studies
• Humans
• Intestinal Polyps (complications, diagnosis)
• Intestine, Small (pathology)
• Intussusception (etiology)
• Male
• Peutz-Jeghers Syndrome (diagnosis)
• Retrospective Studies
• Young Adult