Intralesional infiltration of corticosteroids in the treatment of localized Langerhans cell histiocytosis of the mandible: report of two cases.

Abstract

OBJECTIVE:

This study was undertaken to describe 2 cases of localized Langerhans cell histiocytosis (LLCH) of the mandible that healed quickly following intralesional infiltration of corticosteroids.

STUDY DESIGN:

Two patients with LLCH of the mandible were treated in a 1-stage procedure with intralesional injection of methylprednisolone. Symptoms of pain were quickly relieved and the swelling receded. Periodic orthopantomogram and computerized tomography after corticosteroid injection revealed continuous regression of mandibular osteolysis and a favorable osseous consolidation in the lesions.

CONCLUSIONS:

The results of this report suggest that intralesional injection of corticosteroids should be the initial choice of treatment of LLCH of the mandible, especially in children to preserve tooth germs.

• Authors: Sang-Hwa Lee, Hyun-Joong Yoon
• Journal: Oral surgery, oral medicine, oral pathology and oral radiology (Oral Surg Oral Med Oral Pathol Oral Radiol) Vol. 116 Issue 4 Pg. e255-60 (Oct 2013) ISSN: 2212-4411 [Electronic] United States
• PMID: 22771407 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2013 Elsevier Inc. All rights reserved.

Chemical References

• Glucocorticoids
• Methylprednisolone

Topics

• Child
• Child, Preschool
• Female
• Glucocorticoids (administration & dosage)
• Histiocytosis, Langerhans-Cell (diagnostic imaging, drug therapy, pathology)
• Humans
• Injections, Intralesional
• Mandible (diagnostic imaging, pathology)
• Mandibular Diseases (diagnostic imaging, drug therapy, pathology)
• Methylprednisolone (administration & dosage)
• Tomography, X-Ray Computed