SAPHO syndrome with bacillus Calmette-Guerin (BCG) immunotherapy for bladder cancer.

Abstract

The authors describe a case of SAPHO syndrome with bacillus Calmette-Guérin (BCG) immunotherapy for bladder cancer. The patient had undergone transurethral resection (TUR) and was treated with BCG immunotherapy following TUR. Two years after treatment for bladder cancer, the patient had palmoplantar pustulosis, and in the past 1 month suffered from pain localised to the anterior chest wall. The bone scintigraphy showed a strong focal enrichment in the right chest wall, suggesting spondyloarthropathy rather than malignant disease. On the basis of clinical and scintigraphy findings, SAPHO syndrome was diagnosed. The patient was treated with topical therapy and non-steroidal anti-inflammatory drugs and symptoms improved. The authors suggest that SAPHO syndrome might be caused by an association with BCG immunotherapy.

• Authors: Katsuhiko Matsumaru, Kazuki Nagai, Takayuki Murakami, Kazuo Andoh
• Journal: BMJ case reports (BMJ Case Rep) Vol. 2010 Pg. 2591 (Aug 31 2010) ISSN: 1757-790X [Electronic] England
• PMID: 22767524 (Publication Type: Case Reports, Journal Article)

Chemical References

• BCG Vaccine

Topics

• Acquired Hyperostosis Syndrome (chemically induced, diagnosis, therapy)
• Aged, 80 and over
• BCG Vaccine (adverse effects)
• Diagnosis, Differential
• Female
• Humans
• Urinary Bladder Neoplasms (drug therapy)