Inactivation of membrane-bound (Na+ +K+)-ATPase of Yoshida sarcoma cells and cobra venom cytotoxin complex with the glycolipid components of the enzyme system.

Abstract

The molecular mechanisms involved in the inactivation of (Na+ + K+)-stimulated ATPase of Yoshida sarcoma cells by a cytotoxic protein (P6) from cobra venom have been examined. The overall data obtained using purified (Na+ + K+)-stimulated ATPase of Yoshida sarcoma cells suggest that cytotoxin P6 combines with phosphatidyl serine and a glycolipid which are closely associated with (Na+ + K+)-stimulated ATPase which in turn may lead to the inactivation of the enzyme in this cell system.

• Authors: M D Mone, A Zaheer, M J Fialho, B M Braganca
• Journal: Cancer biochemistry biophysics (Cancer Biochem Biophys) Vol. 4 Issue 1 Pg. 37-41 ( 1979) ISSN: 0305-7232 [Print] England
• PMID: 227583 (Publication Type: Journal Article)

Chemical References

• Carbohydrates
• Elapid Venoms
• Glycolipids
• Membrane Lipids
• Phosphatidylserines
• Sodium-Potassium-Exchanging ATPase

Topics

• Animals
• Carbohydrates (analysis)
• Cell Membrane (enzymology)
• Elapid Venoms (pharmacology)
• Glycolipids (physiology)
• Kinetics
• Membrane Lipids (physiology)
• Mice
• Phosphatidylserines (physiology)
• Sarcoma, Yoshida (enzymology)
• Sodium-Potassium-Exchanging ATPase (metabolism)