[Research of xuebijing injection combined with glucocorticoid in treating dermatitis medicamentosa like of trichloroethylene with systemic inflammatory response syndrome].

Abstract

OBJECTIVE:

To study the better efficacy of clinic treatment for dermatitis medicamentosa like of trichloroethylene (DMLT) and observe the clinic efficacy of Xuebejing injection for DMLT patients with systemic inflammatory response syndrome (SIRS).

METHODS:

16 DMLT patients with SIRS were randomly divided into control group (conventional therapy) and xuebijing group (conventional therapy plus xuebijing). We evaluated all the patients with APACHE II before treatment and checked the TNF-alpha in blood at the different time (before treatment and the 7th day of treatment). The total usages, first dosage of medrol and the time of therapy for each group were counted.

RESULTS:

All patients were cured, there was no significant difference according to APACHE II and TNF-alpha before treatment in two groups . The level of TNF-alpha of all the patients were decreased markedly, but more significantly in xuebijing group (P < 0.01). Moreover, the treatment group patients were given relatively less total usages, first dosage of medrol and time of therapy (P < 0.01).

CONCLUSION:

Xuebejing injection combined glucocorticoids can cure DMLT patients with SIRS effectively, and reduce the total usages, first dosage of medrol and time of therapy.

• Authors: Jin-Lin Wang, Jian-Jie Zhang, Shao-Hong Qiu, Li-Hua Deng
• Journal: Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases (Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi) Vol. 30 Issue 1 Pg. 66-7 (Jan 2012) ISSN: 1001-9391 [Print] China
• PMID: 22730693 (Publication Type: English Abstract, Journal Article, Randomized Controlled Trial, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Drugs, Chinese Herbal
• Glucocorticoids
• Tumor Necrosis Factor-alpha
• Xuebijing
• Trichloroethylene

Topics

• APACHE
• Adolescent
• Adult
• Drug Eruptions (drug therapy)
• Drug Therapy, Combination
• Drugs, Chinese Herbal (therapeutic use)
• Female
• Glucocorticoids (therapeutic use)
• Humans
• Male
• Trichloroethylene (toxicity)
• Tumor Necrosis Factor-alpha (blood)
• Young Adult