[Effect of phenibut and its composition with nicotinic acid on hemostasis in rats with brain ischemia].

Abstract

It is shown that, in rats with global cerebral ischemia modeled by a complete irreversible occlusion of the common carotid artery and forced hypotension, the hemostasis is characterized by a shift toward hypercoagulation. A single preventive introduction of phenibut and, to a greater degree, a composition of phenibut with nicotinic acid, in rats with acute cerebral ischemia reduced the extent of disturbances in the hemostasis system of experimental animals.

• Authors: I N Tiurenkov, E V Volotova, D V Kurkin, A A Litvinov, A S Tarasov
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) Vol. 75 Issue 4 Pg. 10-2 ( 2012) ISSN: 0869-2092 [Print] Russia (Federation)
• PMID: 22702103 (Publication Type: Journal Article)

Chemical References

• Anticonvulsants
• Vasodilator Agents
• Niacin
• gamma-Aminobutyric Acid
• 4-amino-3-phenylbutyric acid

Topics

• Animals
• Anticonvulsants (pharmacology)
• Brain Ischemia (drug therapy, physiopathology)
• Hemostasis (drug effects)
• Male
• Niacin (pharmacology)
• Rats
• Rats, Wistar
• Vasodilator Agents (pharmacology)
• gamma-Aminobutyric Acid (analogs & derivatives, pharmacology)