Changes in hormonal profile and seminal parameters with use of aromatase inhibitors in management of infertile men with low testosterone to estradiol ratios.

Abstract

OBJECTIVE:

To compare the effects of 2.5 mg letrozole with those of 1 mg anastrazole daily on the hormonal and semen profiles of a subset of infertile men with low T/E(2) ratios.

DESIGN:

Prospective, nonrandomized study.

SETTING:

Reproductive medicine clinic.

PATIENT(S):

The study group consisted of 29 infertile men with a low serum T/E(2) ratio (<10).

INTERVENTION(S):

Patients were divided into two groups. Group A included 15 patients treated with 2.5 mg letrozole orally once daily for 6 months, and Group B consisted of 14 patients treated with 1 mg anastrazole orally every day for 6 months.

MAIN OUTCOME MEASURE(S):

Hormonal evaluation included measurement of serum FSH, LH, PRL, T, and E(2). In all sperm analyses pretreatment and posttreatment total motile sperm counts (ejaculate volume × concentration × motile fraction) were evaluated.

RESULT(S):

The use of aromatase inhibitors (either letrozole or anastrazole) in cases of infertile men with low T/E(2) ratios improved both hormonal and semen parameters.

CONCLUSION(S):

This study suggests that some men with severe oligospermia, low T levels, and normal gonadotropin concentration may have a treatable endocrinopathy.

• Authors: Odysseas Gregoriou, Panagiotis Bakas, Charalampos Grigoriadis, Maria Creatsa, Dimitrios Hassiakos, Georgios Creatsas
• Journal: Fertility and sterility (Fertil Steril) Vol. 98 Issue 1 Pg. 48-51 (Jul 2012) ISSN: 1556-5653 [Electronic] United States
• PMID: 22579129 (Publication Type: Clinical Trial, Journal Article)
• Copyright: Copyright © 2012 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

Chemical References

• Aromatase Inhibitors
• Hormones
• Nitriles
• Triazoles
• Anastrozole
• Testosterone
• Estradiol
• Letrozole

Topics

• Adult
• Anastrozole
• Aromatase Inhibitors (adverse effects, pharmacology, therapeutic use)
• Estradiol (analysis, blood)
• Hormones (blood, metabolism)
• Humans
• Infertility, Male (blood, drug therapy, pathology)
• Letrozole
• Male
• Nitriles (adverse effects, pharmacology, therapeutic use)
• Organ Size (drug effects)
• Semen Analysis
• Testis (drug effects, pathology)
• Testosterone (analysis, blood)
• Triazoles (adverse effects, pharmacology, therapeutic use)