New metabolites from the marine-derived fungus Aspergillus fumigatus.

Abstract

A new alkaloid, fumiquinazoline K (1), and a new nordammarane triterpenoid (2), together with three known diketopiperazines (3-5) and tryptoquivaline F (6) have been isolated from a marine strain of Aspergillus fumigatus KMM 4 631 associated with the soft coral Sinularia sp. Their structures were determined by HR-MS and 1D and 2D NMR. Compounds 3-5 exhibit weak cytotoxicity against cytoplasm non-specific esterase in Ehrlich carcinoma cells. Compound 3 also induces early apoptosis of the same cells in a non-toxic range of concentrations.

• Authors: Shamil Sh Afiyatullov, Olesya I Zhuravleva, Alexandr S Antonov, Anatoly I Kalinovsky, Michail V Pivkin, Ekaterina S Menchinskaya, Dmitry L Aminin
• Journal: Natural product communications (Nat Prod Commun) Vol. 7 Issue 4 Pg. 497-500 (Apr 2012) ISSN: 1934-578X [Print] United States
• PMID: 22574452 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Alkaloids
• Antineoplastic Agents
• Quinazolines
• Triterpenes
• fumiquinazoline K

Topics

• Alkaloids (chemistry, isolation & purification)
• Animals
• Anthozoa (microbiology)
• Antineoplastic Agents (isolation & purification)
• Aspergillus fumigatus (chemistry, metabolism)
• Mice
• Quinazolines (chemistry, isolation & purification)
• Triterpenes (chemistry, isolation & purification)