Indacaterol: a novel long-acting β(2) -agonist.

Abstract

Bronchodilator drugs are the foundation for the treatment of chronic obstructive pulmonary disease. The principal inhaled bronchodilator treatments used are β(2) -agonists and anticholinergics, either alone or in combination. Currently available β(2) -agonists are of either short duration and used multiple times/day, or of long duration, which requires twice-daily administration. Indacaterol is considered an ultra-long-acting β(2) -agonist and was recently approved for use in the United States. Its duration of action is approximately 24 hours, allowing for once-daily administration. Cough was the most commonly reported adverse effect with use of indacaterol. Cough usually occurred within 15 seconds of inhalation of the drug, lasted around 6 seconds, was not associated with bronchospasm, and did not cause discontinuation of the drug. Otherwise, the drug's safety profile was similar to that of other bronchodilators. Based on similar improvement in spirometric measurements compared with other bronchodilator drugs and the convenience of its once-daily dosing, indacaterol may be beneficial in the management of mild-to-moderate chronic obstructive pulmonary disease, either alone or in combination with anticholinergic drugs administered once/day.

• Authors: Shaunta' M Ray, James C McMillen, Sarah A Treadway, Robert S Helmer, Andrea S Franks
• Journal: Pharmacotherapy (Pharmacotherapy) Vol. 32 Issue 5 Pg. 456-74 (May 2012) ISSN: 1875-9114 [Electronic] United States
• PMID: 22499359 (Publication Type: Journal Article, Review)
• Copyright: © 2012 Pharmacotherapy Publications, Inc.

Chemical References

• Adrenergic beta-2 Receptor Agonists
• Delayed-Action Preparations
• Indans
• Quinolones
• indacaterol

Topics

• Administration, Inhalation
• Adrenergic beta-2 Receptor Agonists (administration & dosage, adverse effects, therapeutic use)
• Asthma (drug therapy, metabolism)
• Clinical Trials as Topic
• Delayed-Action Preparations
• Dose-Response Relationship, Drug
• Drug Administration Schedule
• Dry Powder Inhalers
• Humans
• Indans (administration & dosage, adverse effects, therapeutic use)
• Metered Dose Inhalers
• Pulmonary Disease, Chronic Obstructive (drug therapy, metabolism)
• Quinolones (administration & dosage, adverse effects, therapeutic use)
• Treatment Outcome