Abstract |
The surface of all tissues, including the stratum corneum, carries a negative charge. Following that fact it is assumed that a positively charged topical formulation could lead to an enhanced penetration because of an increased interaction with the negative charge of the membrane. The intention of this study is to prove an enhanced penetration of a positively charged nanoemulsion compared to a negatively charged nanoemulsion, both containing prednicarbate. The release and penetration of these nanoemulsions, produced with the high pressure homogenization method, were investigated. Regarding these results reveals that the release of the negatively charged formulation is higher compared to the positively charged nanoemulsion, while the penetration of the positively charged nanoemulsion is enhanced compared to the negatively charged formulation. The results of the investigated positively charged nanoemulsion containing prednicarbate show that its topical use could be advantageous for the therapy of atopic dermatitis, especially regarding phytosphingosine, which was responsible for the positive charge.
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Authors | Yücel Baspinar, Hans-Hubert Borchert |
Journal | International journal of pharmaceutics
(Int J Pharm)
Vol. 430
Issue 1-2
Pg. 247-52
(Jul 01 2012)
ISSN: 1873-3476 [Electronic] Netherlands |
PMID | 22486953
(Publication Type: Comparative Study, Journal Article)
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Copyright | Copyright © 2012 Elsevier B.V. All rights reserved. |
Chemical References |
- Drug Carriers
- Emulsifying Agents
- Emulsions
- Glucocorticoids
- Myristic Acid
- Prednisolone
- phytosphingosine
- Sphingosine
- prednicarbate
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Topics |
- Administration, Cutaneous
- Chemistry, Pharmaceutical
- Drug Carriers
- Drug Compounding
- Drug Stability
- Emulsifying Agents
(chemistry)
- Emulsions
- Glucocorticoids
(administration & dosage, chemistry, metabolism)
- Kinetics
- Myristic Acid
(chemistry, metabolism, pharmacology)
- Nanoparticles
- Nanotechnology
- Permeability
- Prednisolone
(administration & dosage, analogs & derivatives, chemistry, metabolism)
- Pressure
- Skin
(drug effects, metabolism)
- Skin Absorption
(drug effects)
- Solubility
- Sphingosine
(analogs & derivatives, chemistry, metabolism, pharmacology)
- Surface Properties
- Technology, Pharmaceutical
(methods)
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