Ischemic neuroprotection by TRPV1 receptor-induced hypothermia.

Abstract

Although treatment of stroke patients with mild hypothermia is a promising therapeutic approach, chemicals inducing prompt and safe reduction of body temperature are an unmet need. We measured the effects of the transient receptor potential vanilloid-1 (TRPV1) agonist rinvanil on thermoregulation and ischemic brain injury in mice. Intraperitoneal or intracerebroventricular injection of rinvanil induces mild hypothermia that is prevented by the receptor antagonist capsazepine. Both intraischemic and postischemic treatments provide permanent neuroprotection in animals subjected to transient middle cerebral artery occlusion (MCAo), an effect lost in mice artificially kept normothermic. Data indicate that TRPV1 receptor agonists are promising candidates for hypothermic treatment of stroke.

• Authors: Mirko Muzzi, Roberta Felici, Leonardo Cavone, Elisabetta Gerace, Alberto Minassi, Giovanni Appendino, Flavio Moroni, Alberto Chiarugi
• Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (J Cereb Blood Flow Metab) Vol. 32 Issue 6 Pg. 978-82 (Jun 2012) ISSN: 1559-7016 [Electronic] United States
• PMID: 22434066 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Neuroprotective Agents
• TRPV Cation Channels
• TRPV1 protein, mouse

Topics

• Animals
• Brain Ischemia (therapy)
• Hypothermia, Induced (methods)
• Male
• Mice
• Neuroprotective Agents (pharmacology)
• Stroke (therapy)
• TRPV Cation Channels (agonists)