Effects of lithium and valproate on oxidative stress and behavioral changes induced by administration of m-AMPH.

Abstract

In the last years our research group has studied and validated the animal model of mania induced by dextroamphetamine (d-AMPH). Considering the lack of animal models of mania reported in the literature; this study evaluated the possibilities to validate the animal model induced by methamphetamine (m-AMPH). Then, we evaluated the effects of lithium (Li), valproate (VPA) on the behavior and parameters of oxidative damage in rat brain after administration of m-AMPH. In the prevention treatment, Wistar rats were pretreated with Li, VPA or saline (Sal) for 14 days, and then, between days 8 and 14, rats were treated with m-AMPH (1, 0.5 or 0.25 mg/kg) or Sal. In the reversal treatment, rats were first given m-AMPH (0.25 mg/kg) or Sal. Locomotor behavior was assessed using the open-field task and parameters of oxidative damage were measured in brain structures. Our results show that the hyperactivity was prevented and reverted by Li and VPA only when m-AMPH was administered in the dose of 0.25mg/kg. In addition, the m-AMPH in all doses administrated induced oxidative damage in both structures tested in two models. Li and VPA reversed and prevented this impairment, however in a way dependent of cerebral area, the dose of m-AMPH and technique.

• Authors: Dayane D da-Rosa, Samira S Valvassori, Amanda V Steckert, Felipe Ornell, Camila L Ferreira, Jéssica Lopes-Borges, Roger B Varela, Felipe Dal-Pizzol, Monica L Andersen, João Quevedo
• Journal: Psychiatry research (Psychiatry Res) Vol. 198 Issue 3 Pg. 521-6 (Aug 15 2012) ISSN: 1872-7123 [Electronic] Ireland
• PMID: 22429481 (Publication Type: Journal Article)
• Copyright: Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Antimanic Agents
• Lithium Compounds
• Thiobarbituric Acid Reactive Substances
• Methamphetamine
• Valproic Acid

Topics

• Animals
• Antimanic Agents (pharmacology, therapeutic use)
• Bipolar Disorder (drug therapy, metabolism, prevention & control, psychology)
• Brain (drug effects, metabolism)
• Disease Models, Animal
• Dose-Response Relationship, Drug
• Lithium Compounds (pharmacology, therapeutic use)
• Male
• Methamphetamine
• Motor Activity (drug effects)
• Oxidative Stress (drug effects)
• Protein Carbonylation (drug effects)
• Rats
• Rats, Wistar
• Thiobarbituric Acid Reactive Substances (metabolism)
• Valproic Acid (pharmacology, therapeutic use)