Fragrance material review on 2,2,5-trimethyl-5-pentylcyclopentanone.

Abstract

A toxicologic and dermatologic review of 2,2,5-trimethyl-5-pentylcyclopentanone when used as a fragrance ingredient is presented. 2,2,5-trimethyl-5-pentylcyclopentanone is a member of the fragrance structural group Ketones Cyclopentanones and Cyclopentenones. The common characteristic structural element of the group members is a cyclopentanone or cyclopentenone ring with a straight or branched chain alkane or alkene substituent. This review contains a detailed summary of all available toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. Available data for 2,2,5-trimethyl-5-pentylcyclopentanone were evaluated then summarized and includes physical properties, acute toxicity, skin irritation, mucous membrane (eye) irritation, skin sensitization, and phototoxicity data. A safety assessment of the entire Ketones Cyclopentanones and Cyclopentenones will be published simultaneously with this document; please refer to Belsito et al. (2012) for an overall assessment of the safe use of this material and all Ketones Cyclopentanones and Cyclopentenones in fragrances.

• Authors: J Scognamiglio, L Jones, C S Letizia, A M Api
• Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association (Food Chem Toxicol) Vol. 50 Suppl 3 Pg. S668-72 (Oct 2012) ISSN: 1873-6351 [Electronic] England
• PMID: 22425688 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2012 Elsevier Ltd. All rights reserved.

Chemical References

• 2,2,5-trimethyl-5-pentylcyclopentanone
• Cyclopentanes
• Perfume

Topics

• Animals
• Cyclopentanes (pharmacokinetics, toxicity)
• Female
• Humans
• Male
• Perfume
• Rabbits
• Rats
• Skin (drug effects)
• Toxicity Tests