Newly emerging clones of Bordetella pertussis carrying prn2 and ptxP3 alleles implicated in Australian pertussis epidemic in 2008-2010.

Abstract

Australia is experiencing a prolonged epidemic of pertussis that began in 2008. A total of 194 Bordetella pertussis isolates collected from 2008 through 2010 were typed by single-nucleotide polymorphism (SNP) analysis, by multilocus variable number tandem repeats analysis, and by fim3, prn, and ptxP sequence analyses. Strains with 2 closely related SNP profiles carrying prn2 and ptxP3 from the recently emerged SNP cluster I predominated. The data suggest increasing selection among the B. pertussis population in Australia in favor of strains carrying prn2 and ptxP3 under the pressure of acellular vaccine-induced immunity.

• Authors: Sophie Octavia, Vitali Sintchenko, Gwendolyn L Gilbert, Andrew Lawrence, Anthony D Keil, Geoff Hogg, Ruiting Lan
• Journal: The Journal of infectious diseases (J Infect Dis) Vol. 205 Issue 8 Pg. 1220-4 (Apr 15 2012) ISSN: 1537-6613 [Electronic] United States
• PMID: 22416243 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Bacterial Proteins

Topics

• Alleles
• Australia (epidemiology)
• Bacterial Proteins (genetics, metabolism)
• Bordetella pertussis (genetics)
• Epidemics
• Gene Expression Regulation, Bacterial (physiology)
• Humans
• Polymorphism, Genetic
• Whooping Cough (epidemiology, microbiology)