Abstract | OBJECTIVES: MATERIALS AND METHODS: This study involved 59 patients with knee OA, randomised to receive single oral dose of 1,500 mg, GLU-SR and GLU-IR for 60 days with 31 and 28 patients, respectively. The primary efficacy ( pain and function) was assessed using visual analogue scale (VAS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores. Intention-to-treat principle, repeated measure of ANOVA and mixed model analysis were used. RESULTS: The patients baseline, demographic and clinical characteristics were comparable between groups with female preponderance (71.20%). There was a significant reduction in algofunctional indices as primary outcome measure in both the groups across time (P < 0.001) and 29% lesser adverse events (AEs) in GLU-SR group, with no difference in the use of rescue medications. CONCLUSIONS: The study showed equal efficacy of the glucosamine formulations on algofunctional indices in reducing pain in patients with knee OA with less number of AEs in GLU-SR.
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Authors | Chanda Kulkarni, A Leena, K Lohit, Devesh Mishra, M J Saji |
Journal | Journal of pharmacology & pharmacotherapeutics
(J Pharmacol Pharmacother)
Vol. 3
Issue 1
Pg. 48-54
(Jan 2012)
ISSN: 0976-5018 [Electronic] India |
PMID | 22368417
(Publication Type: Journal Article)
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