CpG-enriched plasmid enhances the efficacy of the traditional foot-and-mouth disease killed vaccine.

Abstract

A CpG-enriched recombinant plasmid (pUC18-CpG) as an adjuvant of FMD killed vaccine was tested for immunization and vaccination challenge in a porcine model. Our preliminary results had indicated that the recombinant plasmid could enhance the humoral immune response triggered by the traditional oil-adjuvant vaccine after the initial inoculation. A subsequent vaccination-challenge test showed an increased PD(50) value. Thus, coadministration of the recombinant plasmid with the oil-adjuvant vaccine helped illicit an immune response earlier than that elicited by giving the vaccine alone. Our results showed that pUC18-CpG can be a potent immunoadjuvant for the traditional FMD killed vaccine and can greatly enhance the traditional vaccine's efficacy when given in combination with it.

• Authors: Xiaoyu Guo, Hong Jia, Quan Zhang, Weifeng Yuan, Gang Zhu, Ting Xin, Hongfei Zhu, José Manuel Sánchez-Vizcaíno
• Journal: Microbiology and immunology (Microbiol Immunol) Vol. 56 Issue 5 Pg. 332-7 (May 2012) ISSN: 1348-0421 [Electronic] Australia
• PMID: 22335800 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2012 The Societies and Blackwell Publishing Asia Pty Ltd.

Chemical References

• Adjuvants, Immunologic
• Antibodies, Viral
• Vaccines, Inactivated
• Viral Vaccines

Topics

• Adjuvants, Immunologic (administration & dosage, genetics)
• Animals
• Antibodies, Viral (immunology)
• Foot-and-Mouth Disease (immunology, prevention & control, virology)
• Foot-and-Mouth Disease Virus (genetics, immunology)
• Plasmids (administration & dosage, genetics, immunology)
• Swine
• Swine Diseases (immunology, prevention & control, virology)
• Vaccination
• Vaccines, Inactivated (administration & dosage, genetics, immunology)
• Viral Vaccines (administration & dosage, genetics, immunology)