Abstract | OBJECTIVES: Donor safety is one of the most important aspects of living-donor liver transplant. The preoperative evaluation of candidates for such transplants essentially starts with serologic and biochemical analyses. However, some potential liver donors with normal liver function test results may have isolated mild hyperbilirubinemia (serum indirect bilirubin level > 20.5 μmol/L [1.2 mg/dL]). Gilbert syndrome is an autosomal recessive condition that is a common cause of nonhemolytic unconjugated hyperbilirubinemia, and its prevalence is 3% to 10% in the healthy US population. Mild hyperbilirubinemia episodes are expected in people with Gilbert syndrome when they are exposed to physical stress, such as operative intervention or low energy intake. The liver morphologic findings of these individuals are normal; however, there is a debate on the use of people with Gilbert syndrome as living-liver donors. The purpose of this study was to assess the results of right-lobe living-donor hepatectomy of liver donors with Gilbert syndrome. MATERIALS AND METHODS: RESULTS: The median follow-up after transplant was 34 months (range, 18 to 51 mo). One week after the operation, the median bilirubin level for right-lobe liver donors was 34.5 μmol/L (2.02 mg/dL) (range, 17.1 to 51.3 μmol/L [1 to 3 mg/dL]), and the median prothrombin time (international normalized ratio) was 1.36 (range, 1.1 to 1.7). The median bilirubin level of the donors after 6 months was 29 μmol/L (1.7 mg/dL) (range, 20.5 to 41 μmol/L [1.2 to 2.4 mg/dL]). CONCLUSIONS:
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Authors | Tolga Demirbas, Turgut Piskin, Murat Dayangac, Onur Yaprak, Murat Akyildiz, Yaman Tokat, Yildiray Yuzer |
Journal | Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation
(Exp Clin Transplant)
Vol. 10
Issue 1
Pg. 39-42
(Feb 2012)
ISSN: 2146-8427 [Electronic] Turkey |
PMID | 22309418
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Bilirubin
(blood)
- Female
- Follow-Up Studies
- Gilbert Disease
(blood, complications)
- Graft Survival
(physiology)
- Hepatectomy
(methods)
- Humans
- Hyperbilirubinemia
(blood, etiology)
- Liver
(surgery)
- Liver Failure
(surgery)
- Liver Function Tests
- Liver Transplantation
(adverse effects, methods, physiology)
- Living Donors
- Male
- Middle Aged
- Outcome Assessment, Health Care
- Patient Safety
- Retrospective Studies
- Treatment Outcome
- Young Adult
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