Pulmonary veno-occlusive disease following reduced-intensity allogeneic bone marrow transplantation for acute myeloid leukemia.

Abstract

We report a case of pulmonary veno-occlusive disease (PVOD) following allogeneic bone marrow transplantation (BMT) for the treatment of acute myeloid leukemia (AML) from an HLA mismatched mother using a reduced-intensity conditioning (RIC) regimen including gemtuzumab ozogamicin. The patient was a 21-year-old male who complained of dyspnea with hypoxemia followed by loss of consciousness. The abnormalities in chest CT and echocardiography were compatible with a diagnosis of PVOD. Treatment with 1 mg/kg of oral prednisolone resolved dyspnea and hypoxemia within a few days, and chest CT abnormalities disappeared in a week. This report is the first to describe PVOD following RIC stem cell transplantation.

• Authors: Kohei Hosokawa, Hirohito Yamazaki, Masaru Nishitsuji, Satoshi Kobayashi, Akiyoshi Takami, Masaki Fujimura, Shinji Nakao
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 51 Issue 2 Pg. 195-8 ( 2012) ISSN: 1349-7235 [Electronic] Japan
• PMID: 22246490 (Publication Type: Case Reports, Journal Article)

Topics

• Bone Marrow Transplantation (adverse effects)
• Diagnosis, Differential
• Humans
• Leukemia, Myeloid, Acute (surgery)
• Male
• Pulmonary Veno-Occlusive Disease (diagnosis, etiology)
• Transplantation Conditioning (adverse effects)
• Young Adult