Abstract | AIMS/HYPOTHESIS: METHODS: Seventy-one patients (age 18-70 years), who did not reach HbA(1c) 6.5% (48 mmol/mol) with lifestyle and/or metformin, sulfonylurea or glinide therapy, participated in this 16 week, double-centre (university hospitals) Pbo-controlled parallel-group study. All participants, people doing measurements or examinations, and people assessing the outcomes were blinded to group assignment. Fasting TG 1.7-5.0 mmol/l was among the entry criteria. Patients received a high-fat mixed meal before and 4 and 16 weeks after randomisation (allocation by central office) to Alo (n = 25), Alo/Pio (n = 22) or Pbo (n = 24). Blood was sampled at pre-specified intervals, starting at 15 min before and ending 8 h after meal ingestion. RESULTS: At week 16, Alo (n = 25) and Alo/Pio (n = 21) vs Pbo (n = 24) produced similar significant reductions in total postprandial TG response (incremental AUC [iAUC]; p < 0.001), as well as in chylomicron TG (p < 0.001) and VLDL1 TG iAUCs (p < 0.001 and p = 0.012, respectively). Postprandial chylomicron apolipoprotein B-48 iAUC showed a significant decrease after Alo treatment (p = 0.028), and a non-significant trend towards a decrease with Alo/Pio (p = 0.213). The incidence of adverse events was low and consistent with previous studies. CONCLUSIONS/INTERPRETATION: Treatment with Alo and Alo/Pio produced significant reductions in postprandial TG and TG-rich lipoproteins, contributing to an improved overall cardiometabolic risk profile in type 2 diabetes. The data support the concept that incretins not only modulate glucose metabolism but also influence chylomicron metabolism in intestinal cells. TRIAL REGISTRATION: ClinicalTrials.gov number NCT00655863.
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Authors | B Eliasson, D Möller-Goede, K Eeg-Olofsson, C Wilson, J Cederholm, P Fleck, M Diamant, M-R Taskinen, U Smith |
Journal | Diabetologia
(Diabetologia)
Vol. 55
Issue 4
Pg. 915-25
(Apr 2012)
ISSN: 1432-0428 [Electronic] Germany |
PMID | 22237690
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Blood Glucose
- Dipeptidyl-Peptidase IV Inhibitors
- Hypoglycemic Agents
- Insulin
- Lipids
- Piperidines
- Thiazolidinediones
- Uracil
- alogliptin
- Pioglitazone
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Topics |
- Adult
- Aged
- Blood Glucose
- Diabetes Mellitus, Type 2
(blood, drug therapy)
- Dipeptidyl-Peptidase IV Inhibitors
(pharmacology, therapeutic use)
- Double-Blind Method
- Female
- Humans
- Hypoglycemic Agents
(pharmacology, therapeutic use)
- Insulin
(blood)
- Lipids
(blood)
- Male
- Middle Aged
- Pioglitazone
- Piperidines
(pharmacology, therapeutic use)
- Postprandial Period
(drug effects)
- Thiazolidinediones
(pharmacology, therapeutic use)
- Treatment Outcome
- Uracil
(analogs & derivatives, pharmacology, therapeutic use)
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